Short-versus Long-course Preoperative Radiotherapy plus Delayed Surgery for Rectal Cancer: a Meta-analysis
نویسندگان
چکیده
Long-course chemo-radiotherapy (45~50 Gy in 25 fractions) with delayed surgery or short-course radiotherapy (25 Gy in 5 fractions) with immediate surgery were the most frequent regimens for the treatment of localized and locally advanced resectable rectal cancer (SWEDISH RECTAL CANCER TRIAL, 1997; Colorectal Cancer Collaborative Group, 2001; Kapiteijn et al., 2001; Sauer et al., 2004). Compared with postoperative chemo-radiotherapy, this neoadjuvant strategy improved local control and was associated with reduced toxicity and better compliance of radiotherapy (Frykholm et al., 1993; Sauer et al., 2004; Sebag-Montefiore et al., 2009). The MRC (Medical Research Council) CR07 rectal
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Preoperative short- vs. long-course chemoradiotherapy with delayed surgery for locally advanced rectal cancer
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متن کاملIn the literature: April 2017
SHORT-COURSE RADIOTHERAPY FOLLOWED BY DELAYED SURGERY BECOMES A VALIDATED ALTERNATIVE TO TREAT INTERMEDIATE-RISK LOCALISED RECTAL CANCER The full publication in Lancet Oncology of the Stockholm III trial helps us to understand that short-course radiotherapy in patients with localised rectal cancer could also be followed by delayed surgery. During more than 14 years, more than 800 patients with ...
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